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Meropenem / Vaborbactam Dosage

Medically reviewed by Drugs.com. Last updated on Nov 20, 2023.

Applies to the following strengths: 1 g-1 g

Usual Adult Dose for Pyelonephritis

4 g IV every 8 hours
Duration of therapy: Up to 14 days

Use: For the treatment of patients with complicated urinary tract infections (including pyelonephritis) due to susceptible Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae species complex

Usual Adult Dose for Urinary Tract Infection

4 g IV every 8 hours
Duration of therapy: Up to 14 days

Use: For the treatment of patients with complicated urinary tract infections (including pyelonephritis) due to susceptible Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae species complex

Renal Dose Adjustments

Estimated glomerular filtration rate (GFR) at least 50 mL/min/1.73 m2: No adjustment recommended.
Estimated GFR 30 to 49 mL/min/1.73 m2: 2 g IV every 8 hours
Estimated GFR 15 to 29 mL/min/1.73 m2: 2 g IV every 12 hours
Estimated GFR less than 15 mL/min/1.73 m2: 1 g IV every 12 hours

Comments:

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for dosing related precautions.

Dialysis

Hemodialysis: Dose (adjusted for eGFR) should be administered after a hemodialysis session.
Peritoneal dialysis: Data not available

Other Comments

4 g meropenem-vaborbactam contains 2 g meropenem and 2 g vaborbactam
2 g meropenem-vaborbactam contains 1 g meropenem and 1 g vaborbactam
1 g meropenem-vaborbactam contains 0.5 g meropenem and 0.5 g vaborbactam

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.