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Mecamylamine Dosage

Medically reviewed by Drugs.com. Last updated on Dec 4, 2023.

Applies to the following strengths: 2.5 mg

Usual Adult Dose for Hypertension

2.5 mg orally twice a day; may increase by one 2.5 mg tablet at intervals of 2 days or more until desired blood pressure response is achieved.

Comments:


Use: Management of moderately severe to severe essential hypertension and uncomplicated cases of malignant hypertension.

Renal Dose Adjustments

No specific guidelines have been suggested. Caution is recommended; use with great discretion, if at all, when renal insufficiency is manifested by rising or elevated BUN; contraindicated in uremia.

Liver Dose Adjustments

Data not available

Dose Adjustments

Concomitant Use of a Thiazide Diuretic:

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: Post-meal administration may allow for more gradual absorption and smoother control of excessively high blood pressure. Administration in relation to meals should be consistent. Larger doses should be given at noon and perhaps in the evening. The morning dose should be relatively small and in some cases may be omitted.

Monitoring: Monitor blood pressure; measure in the erect position before initiation and with dose increases.

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.