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Maralixibat Dosage

Medically reviewed by Drugs.com. Last updated on Oct 15, 2024.

Applies to the following strengths: 9.5 mg/mL; 19 mg/ml

Usual Adult Dose for Pruritus

Initial dose: 190 mcg/kg orally once a day
Maintenance dose: 380 mcg/kg orally once a day
Maximum dose: 28.5 mg/day (patients over 70 kg)

Comments:


Use: Treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS)

Usual Adult Dose for Pruritus of Partial Biliary Obstruction

Initial dose: 190 mcg/kg orally once a day
Maintenance dose: 380 mcg/kg orally once a day
Maximum dose: 28.5 mg/day (patients over 70 kg)

Comments:


Use: Treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS)

Usual Pediatric Dose for Pruritus

1 year and older:


Comments:

Use: Treatment of cholestatic pruritus in patients with ALGS

Usual Pediatric Dose for Pruritus of Partial Biliary Obstruction

1 year and older:


Comments:

Use: Treatment of cholestatic pruritus in patients with ALGS

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Patients with clinically significant portal hypertension, decompensated cirrhosis, and/or hepatic decompensation: Data not available

Baseline liver function tests (e.g., ALT, AST, direct bilirubin, INR, total bilirubin) should be obtained prior to starting treatment, and then levels should be monitored throughout treatment.

If abnormalities develop during therapy in the absence of other causes:


Hepatic decompensation events (e.g., ascites, hepatic encephalopathy, variceal hemorrhage): Treatment should be permanently discontinued.

Dose Adjustments

Gastrointestinal Adverse Events:


Fat-Soluble Vitamin (FSV) Deficiency:

Precautions

CONTRAINDICATIONS: None.

Safety and efficacy have not been established in patients younger than 1 year.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.