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Irinotecan Liposomal Dosage

Medically reviewed by Drugs.com. Last updated on Apr 3, 2024.

Applies to the following strengths: 4.3 mg/mL

Usual Adult Dose for Pancreatic Cancer

70 mg/m2 IV over 90 minutes every 2 weeks

Comments:


Use: Indicated in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Serum bilirubin above upper limit of normal: Data not available; the manufacturer product information indicates that there is no recommended dose for this patient population.

Dose Adjustments

HOMOZYGOUS UGT1A1*28 ALLELE:


GRADE 3 or 4 ADVERSE REACTIONS:

INTERSTITIAL LUNG DISEASE OR ANAPHYLACTIC REACTION:

STRONG CYP450 3A4 INDUCER or INHIBITOR and STRONG UGT1A1 INHIBITOR:

Precautions

US BOXED WARNINGS:
SEVERE NEUTROPENIA:

SEVERE DIARRHEA:

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

General:

General:

Monitoring:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.