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Interferon Beta-1A Dosage

Medically reviewed by Drugs.com. Last updated on Aug 4, 2023.

Applies to the following strengths: 22 mcg/0.5 mL; 44 mcg/0.5 mL; 30 mcg; 30 mcg/0.5 mL

Usual Adult Dose for Multiple Sclerosis

TITRATION DOSE TO REDUCE THE INCIDENCE AND SEVERITY OF INFLUENZA-LIKE SYMPTOMS:
Week 1: 7.5 mcg IM once a week
Week 2: 15 mcg IM once a week
Week 3: 22.5 mcg IM once a week
Week 4+: 30 mcg IM once a week

TITRATION DOSE FOR 22 MCG:
Weeks 1 to 2: 4.4 mcg subcutaneously 3 times a week
Weeks 3 to 4: 11 mcg subcutaneously 3 times a week
Weeks 5+: 22 mcg subcutaneously 3 times a week
TITRATION DOSE FOR 44 MCG:
Weeks 1 to 2: 8.8 mcg subcutaneously 3 times a week
Weeks 3 to 4: 22 mcg subcutaneously 3 times a week
Weeks 5+: 44 mcg subcutaneously 3 times a week

Use: For the treatment of patients with relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations. Patients with multiple sclerosis in whom efficacy has been demonstrated include patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Rebif(R): The manufacturer recommends caution when initiating this drug in patients with active liver disease, a history of significant liver disease, alcohol abuse, or increased serum SGPT (greater than 2.5 times ULN).

Dose Adjustments

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.