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Insulin Degludec / Liraglutide Dosage

Medically reviewed by Drugs.com. Last updated on Mar 27, 2024.

Applies to the following strengths: 100 units-3.6 mg/mL

Usual Adult Dose for Diabetes Type 2

Dose is directed in units of insulin degludec

Basal Insulin or GLP-1 Receptor Agonist Naive:


Currently Receiving a Basal Insulin or GLP-1 Receptor Agonist: Discontinue therapy with basal insulin and/or liraglutide prior to initiating:

TITRATION: Adjust dose up or down in increments of 2 units every 3 to 4 days based on individual metabolic needs, blood glucose monitoring, and glycemic goal until desired fasting plasma glucose is achieved
Maximum daily dose: 50 units (insulin degludec 50 units; liraglutide 1.8 mg)

Comments:

Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Renal Dose Adjustments

Mild and Moderate Renal Impairment: No specific dose adjustments provided, however, glucose monitoring should be intensified and dose adjustments made on an individual basis

Liver Dose Adjustments

No specific dose adjustments provided, however, glucose monitoring should be intensified and dose adjustments made on an individual basis

Dose Adjustments

Elderly: Initial dosing, dose increments, and maintenance dosage should be conservative to avoid hypoglycemic reactions.

To minimize the risk of hypoglycemia or hyperglycemia, additional titration may be necessary with changes in physical activity, food intake, during acute illness, or with use of concomitant medications.

Missed doses:

Precautions

US BOXED WARNING: Risk of Thyroid C-Cell Tumors:


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

Compatibility: Do not mix with any other products; do not add to infusion fluids

General:

Monitoring:

Patient advice:

Frequently asked questions

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.