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Immune Globulin Subcutaneous Dosage

Medically reviewed by Drugs.com. Last updated on Feb 16, 2024.

Applies to the following strengths: 160 mg/mL; hipp 165 mg/mL; 20%; klhw 20%

Usual Adult Dose for Primary Immunodeficiency Syndrome

Initial weekly dose of Hizentra(R): [Previous IGIV dose (in grams)/number of weeks between IGIV doses] x 1.37
Infusion rate and volume:
First infusion: Rate of 15 mL/hr/site, volume of 15 mL or less per site
Second to fourth infusion: Rate of 25 mL/hr/site, volume of 15 mL or less per site
Fifth infusion: Rate of 25 mL/hr/site, volume of 20 mL or less per site
Sixth infusion and onward: Rate of 25 mL/hr/site, volume of 25 mL or less per site

Initial weekly dose of Cuvitru(R): [Previous IGIV or Hyqvia(R) dose (in grams)/number of weeks between IGIV doses] x 1.30
Infusion rate and volume:
First 2 infusions:

Subsequent infusions:


Every 2 week dosing: Start 1 or 2 weeks after last IGIV infusion, or 1 week after last weekly subcutaneous immune globulin infusion. Give twice the calculated weekly dose.

Frequent dosing (2 to 7 times/week): Start 1 week after last IGIV or subcutaneous immune globulin infusion; divide calculated weekly dose by desired number of doses per week.



Comments:

Use(s): Primary humoral immunodeficiency

Usual Pediatric Dose for Primary Immunodeficiency Syndrome

2 years and older:

Initial weekly dose of Hizentra(R): [Previous IGIV dose (in grams)/number of weeks between IGIV doses] x 1.37
Infusion rate and volume:
First infusion: Rate of 15 mL/hr/site, volume of 15 mL or less per site
Second to fourth infusion: Rate of 25 mL/hr/site, volume of 15 mL or less per site
Fifth infusion: Rate of 25 mL/hr/site, volume of 20 mL or less per site
Sixth infusion and onward: Rate of 25 mL/hr/site, volume of 25 mL or less per site

Initial weekly dose of Cuvitru(R): [Previous IGIV or Hyqvia(R) dose (in grams)/number of weeks between IGIV doses] x 1.30
Infusion rate and volume:
First 2 infusions:

Subsequent infusions:


Every 2 week dosing: Start 1 or 2 weeks after last IGIV infusion, or 1 week after last weekly subcutaneous immune globulin infusion. Give twice the calculated weekly dose.

Frequent dosing (2 to 7 times/week): Start 1 week after last IGIV or subcutaneous immune globulin infusion; divide calculated weekly dose by desired number of doses per week.



Comments:

Use(s): Primary humoral immunodeficiency

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Dosage may be adjusted to achieve desired clinical response and serum IgG levels.

Precautions

US BOXED WARNING(S): THROMBOSIS

Recommendations:


Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.