Fotivda Dosage
Generic name: TIVOZANIB HYDROCHLORIDE 0.89mg
Dosage form: capsule
Drug class: VEGF/VEGFR inhibitors
Medically reviewed by Drugs.com. Last updated on Oct 22, 2024.
Recommended Dosing
The recommended dosage of FOTIVDA is 1.34 mg taken orally once daily for 21 days on treatment followed by 7 days off treatment for a 28-day cycle.
Continue treatment until disease progression or until unacceptable toxicity occurs.
Take FOTIVDA with or without food. Swallow the FOTIVDA capsule whole with a glass of water. Do not open the capsule.
If a dose is missed, the next dose should be taken at the next scheduled time. Do nottake two doses at the same time.
Dose Modifications for Adverse Reactions
Initiate medical management for diarrhea, nausea, or vomiting prior to dose interruption or reduction.
If dose modifications are required for adverse reactions, reduce the dosage of FOTIVDA to 0.89 mg for 21 days on treatment followed by 7 days off treatment for a 28-day cycle.
Recommendations for dosage modifications are provided in Table 1.
Adverse Reaction | Severity * | Dosage Modifications for FOTIVDA |
---|---|---|
|
||
Hypertension |
Grade 3 |
|
Grade 4 |
|
|
Cardiac Failure |
Grade 3 |
|
Grade 4 |
|
|
Arterial Thromboembolic Events |
Any Grade |
|
Hemorrhagic Events |
Grade 3 or 4 |
|
Proteinuria |
2 grams or greater proteinuria in 24 hours |
|
Reversible Posterior Leukoencephalopathy Syndrome |
Any Grade |
|
Other Adverse Reactions | Persistent or intolerable Grade 2 or 3 adverse reaction Grade 4 laboratory abnormality |
|
Grade 4 adverse reaction |
|
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