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Fosnetupitant / Palonosetron Dosage

Medically reviewed by Drugs.com. Last updated on May 20, 2024.

Applies to the following strengths: 235 mg-0.25 mg; 235 mg-0.25 mg/20 mL

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

Fosnetupitant 235 mg-palonosetron 0.25 mg via IV infusion over 30 minutes ONCE, starting 30 minutes before chemotherapy on Day 1

ADDITIONAL MEDICATIONS:
Highly Emetogenic Cancer Chemotherapy, Including Cisplatin-Based Chemotherapy:


Use: In combination with dexamethasone for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 to 60 mL/min): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min) and end-stage renal disease: Not recommended.

Liver Dose Adjustments

Mild to moderate liver dysfunction (Child-Pugh score 5 to 8): No adjustment recommended.
Severe liver dysfunction (Child-Pugh score greater than 9): Not recommended.

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

End-stage renal disease requiring hemodialysis: Not recommended.
Peritoneal dialysis: Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.