Doripenem Dosage

Usual Adult Dose for Intraabdominal Infection

500 mg via IV infusion every 8 hours
Duration of therapy: 5 to 14 days

Comments:

• Therapy duration includes possible conversion to oral therapy, after at least 3 days of parenteral therapy and once clinical improvement occurs.

Use: As a single agent for the treatment of complicated intraabdominal infections due to Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, B fragilis, B thetaiotaomicron, B uniformis, B vulgatus, Streptococcus intermedius, S constellatus, and Peptostreptococcus micros

Usual Adult Dose for Pyelonephritis

500 mg via IV infusion every 8 hours
Duration of therapy: 10 days

Comments:

• Therapy duration includes possible conversion to oral therapy, after at least 3 days of parenteral therapy and once clinical improvement occurs.
• Therapy duration can be extended up to 14 days for concurrent bacteremia.

Uses: As a single agent for the treatment of complicated urinary tract infections, including pyelonephritis due to E coli including cases with concurrent bacteremia, K pneumoniae, Proteus mirabilis, P aeruginosa, and Acinetobacter baumannii

Usual Adult Dose for Urinary Tract Infection

500 mg via IV infusion every 8 hours
Duration of therapy: 10 days

Comments:

• Therapy duration includes possible conversion to oral therapy, after at least 3 days of parenteral therapy and once clinical improvement occurs.
• Therapy duration can be extended up to 14 days for concurrent bacteremia.

Uses: As a single agent for the treatment of complicated urinary tract infections, including pyelonephritis due to E coli including cases with concurrent bacteremia, K pneumoniae, Proteus mirabilis, P aeruginosa, and Acinetobacter baumannii

Renal Dose Adjustments

CrCl greater than 50 mL/min: No adjustment recommended.
CrCl 30 to 50 mL/min: 250 mg via IV infusion every 8 hours
CrCl greater than 10 to less than 30 mL/min: 250 mg via IV infusion every 12 hours

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

This drug is hemodialyzable; however, no dose adjustment guidelines have been reported.

Other Comments

Administration advice:

• Administer via IV infusion over 1 hour.

Storage requirements:

• The manufacturer product information should be consulted.

Reconstitution/preparation techniques:

• The manufacturer product information should be consulted.

IV compatibility:

• Compatible: Sterile water for injection; 0.9% sodium chloride (normal saline); 5% dextrose
• Compatibility with other drugs not established; should not mix with or physically add to solutions containing other drugs.

Monitoring:

• Renal: Renal function in patients with renal dysfunction, especially elderly patients

General:

• To reduce the development of drug-resistant organisms and maintain effective therapy, this drug should be used only to treat infections proven or strongly suspected to be caused by susceptible bacteria.
• Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

Patient advice:

• Avoid missing doses and complete the entire course of therapy.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer