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Denileukin Diftitox Dosage

Applies to the following strengths: 150 mcg/mL

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Lymphoma

9 mcg/kg/day or 18 mcg/kg/day by IV infusion over 30 to 60 minutes for 5 consecutive days every 21 days for 8 cycles.

Comments:


Use: Treatment of persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the IL-2 receptor.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

In 2014, marketing of this drug was discontinued in the US.

US BOXED WARNING:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Reconstitution/preparation techniques:

General:

Monitoring:
Cardiovascular: Weight, edema, blood pressure
Laboratory: Serum albumin levels (prior to initiation of each course and more often as clinically indicated)
Ocular: Visual acuity, color vision
Oncologic: CD25 expression of malignant cells (prior to treatment initiation)
Other: Infusion reactions (within 24 hours of infusion administration)

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.