Skip to main content

Darbepoetin Alfa Dosage

Medically reviewed by Drugs.com. Last updated on Feb 16, 2024.

Applies to the following strengths: 25 mcg/mL; 40 mcg/mL; 60 mcg/mL; 100 mcg/mL; 200 mcg/mL; 300 mcg/mL; 40 mcg/0.4 mL; 60 mcg/0.3 mL; 100 mcg/0.5 mL; 150 mcg/0.3 mL; 200 mcg/0.4 mL; 500 mcg/mL; 300 mcg/0.6 mL; 150 mcg/0.75 mL; 25 mcg/0.42 mL; 10 mcg/0.4 mL

Usual Adult Dose for Anemia Associated with Chronic Renal Failure

Chronic Kidney Disease (CKD) Patients Not on Dialysis:
Initial dose: 0.45 mcg/kg IV or subcutaneously once every 4 weeks as appropriate

Comments:


CKD Patients on Dialysis:
Initial dose: 0.45 mcg/kg IV or subcutaneously once a week or 0.75 mcg/kg once every 2 weeks as appropriate

Comments:

Usual Adult Dose for Anemia Associated with Chemotherapy

Initial dose: 2.25 mcg/kg subcutaneously once a week or 500 mcg subcutaneously once every 3 weeks

Duration of therapy: Until completion of chemotherapy course

Comments:


Use: Treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy.

Usual Pediatric Dose for Anemia Associated with Chronic Renal Failure

Less than 18 Years:
Initial dose:


Comments: Initiate treatment when hemoglobin is less than 10 g/dL.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

All chronic kidney disease (CKD) patients:


CKD patients on dialysis:

CKD patients not on dialysis:

Pediatric CKD patients:

Conversion from epoetin alfa to this drug in CKD patients on dialysis:

Conversion from epoetin alfa to this drug in CKD patients not on dialysis:

All chemotherapy patients:

Precautions

US BOXED WARNING(S):


CONTRAINDICATIONS:

Safety and efficacy have not been established in cancer patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

ANEMIA ASSOCIATED WITH CHRONIC KIDNEY DISEASE (CKD):
Adult:
Initial dose: 0.45 mcg/kg IV or subcutaneously once a week or 0.75 mcg/kg once every 2 weeks as appropriate

Comments:


Pediatric (Less than 18 Years):
Initial dose: 0.45 mcg/kg IV or subcutaneously once a week

Comments: Initiate treatment when hemoglobin is less than 10 g/dL.

Other Comments

Administration advice: The manufacturer product information should be consulted.

Storage requirements:


Reconstitution/preparation techniques:

IV compatibility: Do not administer in conjunction with other drug solutions.

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.