Dalfampridine Dosage
Medically reviewed by Drugs.com. Last updated on Sep 12, 2024.
Applies to the following strengths: 10 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Multiple Sclerosis
Maximum dose: 10 mg orally every 12 hours
Comments:
- This drug may be taken with or without food.
- Tablets should be swallowed whole, and not divided, crushed, chewed, or dissolved.
- Patients should not take double or extra doses if a dose is missed.
Use: To improve walking in adult patients with multiple sclerosis (MS) demonstrated by an increase in walking speed
Renal Dose Adjustments
- Mild renal impairment (CrCl 51 to 80 mL/min): Plasma levels of this drug may approach those seen at a dose of 15 mg 2 times a day, a dose that is 1.5 times the maximum recommended dose and may be associated with an increased risk of seizures; because renal impairment is common after age 50, estimating CrCl is particularly important in these patients
- Moderate to severe renal impairment (CrCl less than 51 mL/min): Contraindicated
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to the active component, 4-aminopyridine, or any of the ingredients
- History of seizure
- Moderate or severe renal impairment (CrCl 50 mL/min or less)
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- This drug may be taken with or without food.
- Tablets should be swallowed whole, and not divided, crushed, chewed, or dissolved.
Patient advice:
- Do not take double or extra doses if a dose is missed.
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