Conestat Alfa Dosage

Medically reviewed by Drugs.com. Last updated on May 6, 2024.

Usual Adult Dose for Hereditary Angioedema

Less than 84 kg: 50 international units/kg IV injection once over approximately 5 minutes; may repeat once if symptoms persist.
84 kg or more: 4200 international units IV injection once over approximately 5 minutes; may repeat once if symptoms persist.

Maximum dose: Not to exceed 4200 international units per dose or 2 doses per 24 hours

Usual Pediatric Dose for Hereditary Angioedema

13 Years or Older:
Less than 84 kg: 50 international units/kg IV injection once over approximately 5 minutes; may repeat once if symptoms persist.
84 kg or more: 4200 international units IV injection once over approximately 5 minutes; may repeat once if symptoms persist.

Maximum dose: Not to exceed 4200 international units per dose or 2 doses per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 13 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For IV use after reconstitution only.
• Initiate treatment under the supervision of an experienced healthcare professional; appropriately trained patients may then self-administer.
• The manufacturer product information should be consulted.

Storage requirements:

• Protect from light.
• Store up to 48 months at 2 to 25C (36 to 77F); do not freeze.
• If reconstituted product cannot be used immediately, may store up to 8 hours at 2 to 8C (36 to 46F).

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility: Do not mix or administer with other medicinal products or solutions.

Monitoring: Monitor patients with risk factors for thromboembolic events (e.g., presence of an indwelling venous catheter/access device, prior history of thrombosis, underlying atherosclerosis, use of oral contraceptives or certain androgens, morbid obesity, and immobility) during and after administration of this drug.

Patient advice:

• Advise patients to seek immediate medical attention if early signs and symptoms of hypersensitivity reactions occur (e.g., hives, generalized urticaria, tightness of the chest, wheezing, hypotension, and/or anaphylaxis during or after injection).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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