Casanthranol / Docusate Dosage

Usual Adult Dose for Constipation

1 to 2 capsules or 15 to 30 mL of syrup orally at bedtime; dosage may be increased to 2 capsules or 30 mL of syrup orally twice a day, or 3 capsules orally once at bedtime.

Usual Pediatric Dose for Constipation

<2 years: 5 to 7.5 mL of syrup orally at bedtime.

2 to 11 years: 1 capsule or 5 to 15 mL of syrup orally at bedtime.

>=12 years: 1 to 2 capsules or 15 to 30 mL of syrup orally at bedtime; dosage may be increased to 2 capsules or 30 mL of syrup orally twice a day, or 3 capsules orally once at bedtime.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Casanthranol containing OTC products labeled for laxative use were voluntarily removed from the market by the manufacturers in August 2002 following a report by the FDA, published in May 2002, recognizing them as generally not safe and effective.

The syrup must be given in a 6 to 8 ounce glass of milk, fruit juice or infant's formula to prevent throat irritation.

Bowel movement generally occurs overnight or in 8 to 12 hours following administration.

Prior to using laxatives, consider correcting or modifying underlying factors that may affect bowel function such as lifestyle, disease state, and drug use.

Excessive use of laxatives may lead to dependence and significant fluid and electrolyte imbalance.

Laxative abuse syndrome is most commonly seen in patients suffering from depression, personality disorders, or anorexia nervosa.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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