Rinvoq Alternatives Compared
Rinvoq | Otezla | Methotrexate |
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Rinvoq (upadacitinib) | Otezla (apremilast) | Methotrexate |
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Prescription only
Prescribed for Crohn's Disease, Ankylosing Spondylitis, Atopic Dermatitis, Non-Radiographic Axial Spondyloarthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Rheumatoid... View more |
Prescription only
Otezla is a PDE4 inhibitor that may be used to treat plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet’s Disease. It has been associated with severe diarrhea, nausea, and v... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Related suggestions Popular comparisons
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More about Rinvoq (upadacitinib) | More about Otezla (apremilast) | More about Methotrexate | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Rinvoq has an average rating of 6.8 out of 10 from a total of 172 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
Otezla has an average rating of 5.1 out of 10 from a total of 431 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 41% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 330 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: Rinvoq side effects in more detail. |
See also: Otezla side effects in more detail. |
See also: methotrexate side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Rinvoq prices |
View all Otezla prices |
View all methotrexate prices |
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Dosage Form(s) Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Other upadacitinib brands include: Rinvoq LQ |
N/A |
Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
14 hours |
9 hours |
15 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 550 drugs are known to interact with Rinvoq:
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A total of 86 drugs are known to interact with Otezla:
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A total of 695 drugs are known to interact with methotrexate:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | ||||||||||||||||||||||||||
First Approval Date | ||||||||||||||||||||||||||
August 16, 2019 |
March 21, 2014 |
December 07, 1953 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.