Skip to main content

Nexium Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Nexium Omeprazole Pantoprazole
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Nexium (esomeprazole) Omeprazole Pantoprazole
Prescription only

Nexium effectively heals inflamed tissue in the gastrointestinal tract and relieves symptoms of heartburn. Nexium is available orally and as an IV preparation that may be used in adults and children... View more

Prescription and OTC

Omeprazole decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed areas of gastrointestinal tissue. The risk of interactions with omeprazole... View more

Prescription only

Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to... View more

More about Nexium (esomeprazole) More about Omeprazole More about Pantoprazole
Ratings & Reviews

Nexium has an average rating of 6.1 out of 10 from a total of 210 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 35% reported a negative effect.

Omeprazole has an average rating of 4.6 out of 10 from a total of 490 ratings on Drugs.com. 32% of reviewers reported a positive effect, while 53% reported a negative effect.

Pantoprazole has an average rating of 5.0 out of 10 from a total of 431 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 47% reported a negative effect.

View all 210 reviews

View all 490 reviews

View all 431 reviews

Drug Class
Side Effects

See also: Nexium side effects in more detail.

See also: omeprazole side effects in more detail.

See also: pantoprazole side effects in more detail.
Generic Availability

Lower cost generic approved

Lower cost generic

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 30 delayed release capsule
Dosage 40 mg
Per Unit* $9.98
Cost* $299.40

View all Nexium prices

Quantity 50 each
Dosage 20 mg
Per Unit* $0.42
Cost* $20.93

View all omeprazole prices

Quantity 50 each
Dosage 40 mg
Per Unit* $0.41 - $1.31
Cost* $20.64 - $65.52

View all pantoprazole prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Forms Available
  • Oral delayed release capsule
  • Oral powder for reconstitution, delayed release
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Intravenous powder for injection
  • Intravenous solution
  • Oral delayed release tablet
  • Oral granule, enteric coated
Brand Names
Other esomeprazole brands include: Nexium 24HR, Nexium IV Omesec, Prilosec, Prilosec OTC Protonix, Protonix IV
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

1.5 hours

1.5 hours

1 hour
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
Drug Interactions

A total of 200 drugs are known to interact with Nexium:

  • 22 major drug interactions (57 brand and generic names)
  • 144 moderate drug interactions (1258 brand and generic names)
  • 34 minor drug interactions (187 brand and generic names)

A total of 225 drugs are known to interact with omeprazole:

  • 24 major drug interactions (61 brand and generic names)
  • 153 moderate drug interactions (1281 brand and generic names)
  • 48 minor drug interactions (272 brand and generic names)

A total of 167 drugs are known to interact with pantoprazole:

  • 17 major drug interactions (44 brand and generic names)
  • 131 moderate drug interactions (1194 brand and generic names)
  • 19 minor drug interactions (142 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Food may interfere with the absorption of esomeprazole. Esomeprazole should be taken at least one... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
First Approval Date

N/A

June 20, 2003

February 02, 2000
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Compare Drugs

To view a report comparing 3 (or more) medications, please sign in or create an account.

Create an account Sign In