Perphenazine for Psychosis User Reviews
Perphenazine has an average rating of 6.7 out of 10 from a total of 20 reviews for the treatment of Psychosis. 65% of reviewers reported a positive experience, while 25% reported a negative experience.
Reviews for Perphenazine
- Eric
- Taken for 2 to 5 years
- December 21, 2012
"I have been on Trilafon (perphenazine) for about 4 years. I'm on a low does, 4mg x3 times a day. From what I understand this medicine is a lot more gentle than most medicines that would treat bipolar, schizophrenia, and other forms of psychosis. Its not good for elderly as the higher the dosage you get the more at risk you are for tardiv dyskinesia (or tremors of the face, arms, and hands). I am 28 and this medicine worked when Lexapro, Geodon, Haldol, and risperidone wouldn't. I am given it for Pscyhsis. In addition I am on 40 mg Viibryd and 0.5mg of Klonopin. I would recommend this medicine. "
- Yelll...
- Taken for 6 months to 1 year
- January 13, 2019
Trilafon (perphenazine) "I was prescribed this in 2014 when I was 13 years old. It gave me permanent side effects. They include, WIDENED WAIST that I cannot shrink, weird movements with my face I have to do patterns in every single part of my body, it made me eyes look opposite ways which now in 2019, is still there but not as bad. It made me gain weight, it made my skin dull and grey like I was dead. I wish I could include a picture. It made me have a permanent tremor, too. It's a horrible drug. My posture now sucks and I can't breathe if I try to fix it. I can no longer tan after I took it. I was tan my whole life now my natural tanning peels off and I am white I was never white"
- MomV
- December 8, 2015
"My son has been hospitalized 4 times in the past 5 years.The doctors have prescribed a myriad of of concoctions over these years. I've seen my son go from a healthy 160 teenager to a 210 lb unhealthy sluggish overmedicated sad shell of a person. When he was introduced to perphenazine he seemed to come back to life. But,unfortunately as soon as we see real results he quits taking the pills and it all starts all over again. How can I get my son to stick to taking his medication?Any suggestions??"
- Kelli
- Taken for 6 months to 1 year
- December 5, 2020
"I loved perphenazine except for the movement side effects but Valium helps that. I was recently put on haldol and had a psychotic break so my doc put me back on perphenazine. It helped lower and tame my voices. It’s a wonder med don’t rule out the old meds completely they work. This is someone with schizoaffective disorder."
Are you taking this medicine?
- Anonymous
- Taken for 1 to 6 months
- August 26, 2023
"I have tried a ton of different meds for schizophrenia but all of them either have unbearable side effects or they don't work well enough. I used to be on Zyprexa (Olanzapine) before but it made me gain a ton of weight, it made me really sleepy during the day, and it didn't even work as well as Perphenazine! The weight gain stopped after switching to Perphenazine, and I'm no longer very sleepy during the day. I was really scared to switch to an older drug, but I'm really glad that I tried it. It's still not a miracle cure, but it's a lot better than everything else I have tried. I highly recommend you give Perphenazine a chance! It's also pretty cheap since it's an older drug. My doc recommended that I split the dose in half and take half in the morning when I wake up and the second half before going to bed."
- Ivani...
- Taken for 1 to 6 months
- September 20, 2018
"This medication is very good for anxiety. It worked wonders for my anxiety and paranoia. Helps lower the voice in my head telling me people are out to get me. Zyprexa works well too but I have problems with my memory. It’s hard to deal with and I am wondering how I can deal with the anticholinergic effects from these medications. Any suggestions?"
- Disap...
- November 3, 2016
Trilafon (perphenazine) "I had a very bad experience with perphenazine. I ended up with severe joint pain, difficulty breathing, chest pain, weird spinning sensation in my face on the right side of my nostril, on my forehead and on the right side of my temporal area. I had difficulty urinating and horrible insomnia. It has been well over 6 months since taking up to 12 mg for only a few ( about 2--4 days) and I am still having problems. I started on only 4 mg back in Dec 2013 and took the same dosage up to Mar 2014. I stopped because I could barely urinate. Then, I started have weird movement as stated above in my face, but not as bad as the movement when I took 12mg. The, I was told that I needed to start back on this drug for the movement to disappear."
- trrer
- Taken for 6 months to 1 year
- January 3, 2018
Trilafon (perphenazine) "This really helped my PTSD and major depressive symptoms. Much better than seroquel. Movement side effects when I got up to 12 mg a day. Lowered my dose back down to 8mg a day and the movement side effects went away."
- Perph...
- Taken for less than 1 month
- February 16, 2022
"I just got prescribed this several days ago and it is already helping. I've been on Rexulti for several years for my Schizoaffective disorder related psychosis. However a couple weeks ago I started going through an episode and it just wouldn't go away. So 4 days ago I found myself in psychiatric urgent care to treat my episode and they added the Perphenazine in addition to my normal Rexulti and what I can say is it's already working pretty well. I'm already pretty much back to my normal self. So what I can tell so far is this is a pretty good, effective medication for Schizophrenia and other types of psychosis."
- brain
- Taken for 1 to 6 months
- April 7, 2019
"My sibling was taking this drug, at first it seemed to make her better she would complain of difficulty swallowing and neck stiffness and constipation. After 3 months , she went into delirious state overnight and complained of headache, she was hospitalized in catatonic state, has a MRI and CT scan which revealed fluid build up. All medical tests to find cause of fluid build up came negative. This drug side effect is cerebral edema (fluid buildup) and NMS (neuroleptic malignant syndrome). The fluid build up only becomes clear during CT scan."
- Living
- Taken for 5 to 10 years
- June 22, 2022
Trilafon (perphenazine) "Great drug! Helped get rid of my delusions. I’ve been on it 5 years now and the dose I am taking 8mg at night. Also take 1mg cogentin to prevent the shakes. Risperal and seoquel didn’t help me. Thankful for this drug. Saved my life."
- rita
- Taken for 1 to 2 years
- October 26, 2018
"I have been on medicine from 2016-2018, gained 30-40 pounds. Sometimes it is hard do to anything and I can not focus very well. In the last 4 months, I am having to shuffle my feet and feel like I might fall over. Wish to find other medicine doctor can give me."
- Jabbe...
- Taken for 1 to 6 months
- October 13, 2016
"It was an OK experience for me! I don't think I hit the full effects of it just yet...but Paxil @40mg seems to work much better for me. Tired of trying meds that don't make me too sleepy as well. Also, my appetite was low so I lost a few extra pounds. If I don't see results in another 4 weeks, I'll ask my doctor to put me on Rexulti."
- BKano
- October 8, 2020
"I was put on this drug perphenazine when my Psychosis got 'a little' out of hand after other medications failed. I experienced a very rapid recovery while on Peratsin (perphenazine) and did not need a long-term therapy on the drug. I start the drug occasionally when rapid thoughts and feeling of mania/psychosis start to appear, always helping to resolve and stabilize me. It worked wonders for me but I do know the dangers of the drug, like developing tardive dyskinesia which scares me."
- Jonny...
- Taken for 1 to 6 months
- February 14, 2017
Trilafon (perphenazine) "I was put on this drug, erroneously I believe as I was only suffering a major depressive episode, in 1974. From that time until I went through menopause in 1997 (23 years) I had the side effect galactorrhea. I was never pregnant or post breastfeeding during that time and took no other medication with that side effect."
- Dioge...
- Taken for 1 to 2 years
- September 6, 2022
"I suffer from hebrephrenic schizophrenia, but that diagnosis is now obsolete. Presently, my illness is characterized as undifferentiated shizoaffective disorder. Symptoms included hearing voices, easily distracted and violent rages for no reason. My previous treatment was with mellaril, but for the past 2 years my life has improved dramatically. I am on 32 mg/ day of trilafon, 20 mg of valium, 20 mg / day Celexa , 1500 mg / day depakote and 25 mg/ day dextroamphetamine. This is the most effective combination of drugs that I have ever taken, except my anxiety may require an increase in my valium."
- GTTDD
- Taken for 1 to 6 months
- October 18, 2016
Trilafon (perphenazine) "Not bad! I'm taking other meds as well. I recommend everyone gives it a chance before judging to harshly on this site."
- Jabbe...
- Taken for 1 to 6 months
- October 26, 2016
"Not that bad! Daytime drowsiness."
- Gabs
- Taken for 1 to 6 months
- August 25, 2020
"This drug perphenazine made my psychosis SO much worse. "
- shrim...
- Taken for 6 months to 1 year
- May 30, 2022
"I am on 8MG of this with Seroquel, working quite well!"
Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.
Learn more about Psychosis
Care guides
More about perphenazine
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (37)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: phenothiazine antiemetics
- Breastfeeding
- En español
Trilafon (perphenazine) "I had a similar experience. Tremors in hands (not really noticeable to someone watching unless they were looking for it), but relief from the delusions I was experiencing. My problem has been going on for over 16 years so I anticipate it will not magically disappear (and it didn't) but the clarity of thinking I experience with this medicine really helps me."