Triprolidine

Generic name: triprolidine [ trye-PROE-li-deen ]
Brand names: Histex PD Drops, Histex Syrup, M-Hist PD, PediaClear PD, Histex, ... show all 12 brands Vanaclear PD, Vanahist PD, Zymine, Zymine XR, Tripohist, Histex PDX, Flonase Nighttime Allergy Relief
Dosage form: oral liquid (0.625 mg/mL; 0.938 mg/mL; 2.5 mg/5 mL)
Drug class: Antihistamines

Medically reviewed by Drugs.com on Aug 2, 2023. Written by Cerner Multum.

What is triprolidine?

Triprolidine is an antihistamine that is used to treat sneezing, runny nose, itchy nose and throat, and itchy or watery eyes caused by allergies such as hay fever.

Triprolidine may also be used for purposes not listed in this medication guide.

Triprolidine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Triprolidine may cause serious side effects. Stop using triprolidine and call your doctor at once if you have:

• painful or difficult urination.

Common side effects of triprolidine may include:

• dizziness, drowsiness;

• blurred vision;

• dry mouth, nose, or throat;

• constipation;

• increased urination; or

• feeling nervous or restless (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

You should not use antihistamine medication to make a child sleepy.

Before taking this medicine

You should not use triprolidine if you are allergic to it.

Ask a doctor or pharmacist if triprolidine is safe to use if you have:

• a breathing disorder such as chronic bronchitis or emphysema;

• glaucoma; or

• an enlarged prostate and urination problems.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

This medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).

How should I take triprolidine?

Use exactly as directed on the label, or as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms clear up.

Always follow directions on the medicine label about giving cough or cold medicine to a child. Do not use the medicine only to make a child sleepy. Death can occur from the misuse of cough or cold medicines in very young children.

You must chew the chewable tablet before you swallow it.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Call your doctor if your symptoms do not improve after 7 days, or if you have a fever, rash, or headaches.

If you need surgery or medical tests, tell the doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

Related/similar drugs

prednisone, fluticasone nasal, hydroxyzine, cetirizine, cetirizine ophthalmic, montelukast, loratadine, dexamethasone ophthalmic, diphenhydramine, promethazine

What happens if I miss a dose?

Since triprolidine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking triprolidine?

Avoid driving or hazardous activity until you know how triprolidine will affect you. Your reactions could be impaired.

Drinking alcohol can increase certain side effects of triprolidine.

Ask a doctor or pharmacist before using other cough or cold medicines that may contain similar ingredients.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Triprolidine can decrease sweating and you may be more prone to heat stroke.

What other drugs will affect triprolidine?

Avoid using this medicine with other drugs that cause drowsiness or slow your breathing (such as opioid medicine, a muscle relaxer, or medicine for anxiety or seizures). Ask a doctor or pharmacist before using any other medication, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed in this medication guide.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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