Tauroselcholic Acid Se-75 use while Breastfeeding

Summary of Use during Lactation

Information in this record refers to the use of tauroselcholic acid Se-75 (SeHCAT; selenium-75 homocholic acid taurine) as a diagnostic agent. Information from one patient indicates that the effective radiation dose to the infant from SeHCAT excreted in breastmilk over 6 months is below any established dose limits and no special precautions are required.[1]

Drug Levels

Selenium Se 75 decays by electron capture with a physical half-life of approximately 119 days.

Maternal Levels. A nursing mother who was 3 months postpartum was given a capsule containing 370 kBq of SeHCAT as a diagnostic test. She collected 3 milk samples daily for 7 days. The effective radiation dose to the infant was 7 microSv over the 7-day period and the radiation dose over a 6-month period of exclusive breastfeeding was estimated to be 17 microSv.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.

Coleclough S, Comber E, Adesanya O, Rowley L. Estimation of infant radiation exposure from ingestion of breastmilk after SeHCAT capsule administration. Nucl Med Commun 2023;44:1199-200. doi:10.1097/MNM.0000000000001789 [CrossRef]

Substance Name

Tauroselcholic Acid Se-75

CAS Registry Number

75018-70-1

Drug Class

Breast Feeding

Lactation

Milk, Human

Radiopharmaceuticals

Selenium Radioisotopes

Diagnostic Agents