Because little is available on the use of prazosin during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Drug Levels
Maternal Levels. The manufacturer reports that one mother was studied and excreted at most 3% of the dose into her breastmilk. No study details were presented.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information in nursing mothers was not found as of the revision date. Prazosin does not affect serum prolactin concentration in patients with hypertension.[2,3] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
References
1.
Schaefer C, Peters P, Miller RK eds. Drugs during pregnancy and lactation. Treatment options and risk assessment, 3rd ed. Boston: Academic Press. 2015:716. doi: 10.1016/B978-0-12-408078-2.00001-9. [CrossRef]
2.
Barbieri C, Caldara R, Ferrari C, et al. Metabolic effects of prazosin. Clin Pharmacol Ther. 1980;27:313–6. [PubMed: 6102000]
3.
Barbieri C, Ferrari C, Borzio M, et al. Metabolic effects of chronic prazosin treatment. Horm Metab Res. 1980;12:331–4. [PubMed: 6105121]
Substance Identification
Substance Name
Prazosin
CAS Registry Number
19216-56-9
Drug Class
Breast Feeding
Lactation
Adrenergic alpha-Antagonists
Antihypertensive Agents
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