Based on limited data, amounts of diltiazem ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.
Drug Levels
Maternal Levels. In one patient who was 14 days postpartum, peak milk levels of 190 to 230 mcg/L occurred about 2 hours after the dose during an oral regimen of 60 mg four times daily. The levels and time course of the drug in milk closely paralleled serum levels.[1] Using the peak milk level data from this patient, an exclusively breastfed infant would receive an estimated maximum of 0.9% of the maternal weight-adjusted dosage.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Okada M, Inoue H, Nakamura Y et al. Excretion of diltiazem in human milk. N Engl J Med. 1985;312:992-3. [PubMed: 3974691]
Substance Identification
Substance Name
Diltiazem
CAS Registry Number
42399-41-7
Drug Class
Breast Feeding
Lactation
Antihypertensive Agents
Calcium Channel Blockers
Antiarrhythmics
Vasodilator Agents
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