Zilucoplan Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 19, 2023.

Applies to zilucoplan: subcutaneous solution.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

• fever, chills, sore throat;

• mouth sores, red or swollen gums;

• pale skin, easy bruising, unusual bleeding;

• chest discomfort, wheezing, dry cough or hack, rapid weight loss;

• signs of meningitis--headache, neck stiffness, increased sensitivity to light, nausea, vomiting, confusion, drowsiness; or

• pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting.

Common side effects may include:

• pain, bruising, swelling, or irritation where the medicine was injected;

• cold symptoms such as stuffy nose, sneezing, sore throat; or

• diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to zilucoplan: subcutaneous solution.

General

The most common adverse effects in at least 10% of patients were injection site reactions, upper respiratory tract infections, and diarrhea.^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (11%)

Common (1% to 10%): Nausea, vomiting

Frequency not reported: Pancreatic events^[Ref]

Pancreatic events included pancreatitis and pancreatic cysts.^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection^[Ref]

Local

Very common (10% or more): Injection site reactions (29%)

Other

Common (1% to 10%): Increased lipase, increased amylase

Frequency not reported: Meningococcal infection, transient elevations of blood eosinophils^[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infections (14%)^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer