Vosoritide Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 21, 2023.

Applies to vosoritide: subcutaneous powder for solution.

Serious side effects of Vosoritide

Along with its needed effects, vosoritide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vosoritide:

More common

• Blurred vision
• chills
• confusion
• cough
• diarrhea
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fever
• general feeling of discomfort or illness
• headache
• joint pain
• loss of appetite
• muscle aches and pains
• nausea
• runny nose
• shivering
• sore throat
• sweating
• trouble sleeping
• unusual tiredness or weakness
• vomiting

Other side effects of Vosoritide

Some side effects of vosoritide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Difficulty in moving
• dry skin
• ear pain
• feeling of constant movement of self or surroundings
• hives, itching, rash, redness, swelling, or warmth at the injection site
• muscle pain or stiffness
• pain in the joints
• sensation of spinning
• stomach pain
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

For Healthcare Professionals

Applies to vosoritide: subcutaneous powder for injection.

General

The most common adverse effects were injection site reactions, vomiting, arthralgia, gastroenteritis and decreased blood pressure.^[Ref]

Cardiovascular

Very common (10% or more): Decreased blood pressure (13%)^[Ref]

Dermatologic

Common (1% to 10%): Dry skin^[Ref]

Gastrointestinal

Very common (10% or more): Vomiting (27%), gastroenteritis (13%), diarrhea (10%)

Common (1% to 10%): Nausea^[Ref]

Hypersensitivity

Common (1% to 10%): Seasonal allergy^[Ref]

Immunologic

Very common (10% or more): Anti-drug antibodies (35%)^[Ref]

Local

Very common (10% or more): Injection site reactions (85%) including injection site erythema (75%), injection site swelling (62%), and injection site urticaria (25%)

Frequency not reported: Injection site pain, injection site bruising, injection site pruritus, injection site hemorrhage, injection site discoloration, injection site induration^[Ref]

Metabolic

Common (1% to 10%): Increased alkaline phosphatase^[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (15%)^[Ref]

Nervous system

Common (1% to 10%): Dizziness (included dizziness, syncope, presyncope, procedural dizziness, vertigo)^[Ref]

Other

Common (1% to 10%): Ear pain, fatigue^[Ref]

Respiratory

Very common (10% or more): Influenza (10%)^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer