Vonoprazan Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 21, 2024.

Applies to vonoprazan: oral tablet.

Serious side effects of Vonoprazan

Along with its needed effects, vonoprazan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vonoprazan:

More common

• Burning feeling in the chest or stomach
• indigestion
• stomach upset
• tenderness in the stomach area

Less common

• Anxiety
• black, tarry stools
• bladder pain
• bloody or cloudy urine
• blurred vision
• body or muscle pain
• chest pain
• cold flu-like symptoms
• cough
• diarrhea
• difficult, burning, or painful urination
• discouragement
• dizziness
• eye pain
• fainting
• fast, pounding, or irregular heartbeat or pulse
• feeling sad or empty
• fever or chills
• frequent urge to urinate
• full or bloated feeling
• general feeling of illness
• headache
• irregular heartbeat recurrent
• irritability
• itching of the vagina or genitals
• joint pain
• lack of appetite
• lower back or side pain
• loss of interest or pleasure
• loss of taste or smell
• loss of voice
• nausea or vomiting
• nervousness
• pain or swelling in the arms or legs without any injury
• painful or difficult urination
• pale skin
• pounding in the ears
• slow or fast heartbeat
• sneezing
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stomach pain
• stuffy or runny nose
• swelling of the body or feet and ankles
• swollen glands
• thick, white vaginal discharge with mild or no odor
• trouble breathing
• trouble concentrating
• trouble sleeping
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain

Rare

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• difficulty swallowing
• dizziness or lightheadedness
• dry mouth
• excess air or gas in the stomach
• fainting
• feeling of constant movement of self or surroundings
• flushed, dry skin
• fruit-like breath odor
• increased hunger
• increased thirst
• increased urination
• lack of loss of strength
• loss of consciousness
• sensation of spinning
• sweating
• tingling of the hands or feet
• unexplained weight loss
• vomiting

Incidence not known

• Bleeding gums
• blistering, peeling, or loosening of the skin
• blood in the urine or stools
• chest tightness
• dark urine
• decreased urine
• drowsiness
• hives, itching, skin rash
• joint or muscle pain
• light-colored stools
• loss of appetite
• mood or mental changes
• muscle cramps, pain, spasms, or twitching
• numbness or tingling in the hands, feet, or lips
• pinpoint red spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red irritated eyes
• red skin lesions, often with a purple center
• seizures
• trembling
• vomiting of blood
• watery and severe diarrhea, which may also be bloody
• yellow eyes or skin

Other side effects of Vonoprazan

Some side effects of vonoprazan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach
• belching
• constipation
• heartburn
• passing gas
• pressure in the stomach
• stomach discomfort
• swelling of abdominal or stomach area
• swelling or inflammation of the mouth
• white or brownish vaginal discharge

For Healthcare Professionals

Applies to vonoprazan: oral tablet.

General

The most common adverse reactions occurring in at least 2% of patients treated with this drug across multiple indications (including use in combination with antibacterial agents) included gastritis, diarrhea, abdominal distension, abdominal pain, nausea, dyspepsia, hypertension, urinary tract infection, dysgeusia, vulvovaginal candidiasis, headache, and nasopharyngitis.

For more information on adverse reactions and laboratory changes associated with antibacterial agents (i.e., amoxicillin or clarithromycin) used in combination with this drug refer to the corresponding prescribing information of those agents.^[Ref]

Cardiovascular

Common (1% to 10%): Hypertension

Frequency not reported: Tachycardia, QT prolongation

Dermatologic

Frequency not reported: Eczema, rash, urticaria, dermatitis, dry skin

Postmarketing reports: Drug eruption, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis

Gastrointestinal

Common (1% to 10%): Gastritis, diarrhea, abdominal distension, abdominal pain, nausea, dyspepsia, dysgeusia

Frequency not reported: Duodenal polyp, fundic gland polyps, dry mouth, dysphagia, eructation, flatulence, gastric polyps, vomiting, constipation, duodenal ulcer, flatulence, gastric ulcer, gastroesophageal reflux disease, hematochezia, large intestine polyp, rectal polyp, stomatitis, tongue discomfort, anal fungal infection, gastrointestinal viral infection, oral fungal infection, tongue fungal infection

Genitourinary

Common (1% to 10%): Vulvovaginal candidiasis

Frequency not reported: Vaginal discharge

Hematologic

Frequency not reported: Anemia, lymphocytosis, leukocytosis, leukopenia, neutropenia

Postmarketing reports: Thrombocytopenia

Hepatic

Frequency not reported: Increased liver function test

Postmarketing reports: Hepatic injury, hepatic failure, jaundice

Hypersensitivity

Frequency not reported: Drug hypersensitivity

Postmarketing reports: Anaphylactic shock

Metabolic

Frequency not reported: Diabetes mellitus, decreased appetite

Postmarketing reports: Hypomagnesemia, hypokalemia, hypocalcemia, vitamin B12 deficiency

Musculoskeletal

Frequency not reported: Bone fracture

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Vertigo, dizziness, syncope, ageusia, tension headache

Ocular

Frequency not reported: Orbital edema

Other

Frequency not reported: Asthenia, peripheral edema, fatigue, pyrexia, viral infection

Postmarketing reports: C. difficile (with concomitant antibacterials)

Psychiatric

Frequency not reported: Anxiety, depression, insomnia

Renal

Common (1% to 10%): Urinary tract infection

Frequency not reported: Tubulointerstitial nephritis, renal hypertrophy

Respiratory

Common (1% to 10%): Nasopharyngitis

Frequency not reported: Upper respiratory infection, pneumonia, cough, nasal polyps, oropharyngeal pain

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer