Skip to main content

Troxyca ER Side Effects

Generic name: naltrexone / oxycodone

Medically reviewed by Drugs.com. Last updated on Dec 21, 2023.

Note: This document contains side effect information about naltrexone / oxycodone. Some dosage forms listed on this page may not apply to the brand name Troxyca ER.

Applies to naltrexone / oxycodone: oral capsule extended release.

General

The most frequently reported adverse effects have included nausea, constipation, vomiting, headache, and somnolence.[Ref]

Respiratory

Rhinorrhea, chronic bronchitis, dyspnea, and dysphonia were reported in less than 2% of patients.[Ref]

Common (1% to 10%): Oropharyngeal pain, cough

Frequency not reported: Rhinorrhea, chronic bronchitis, dyspnea, dysphonia[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 20.5%), constipation (up to 14.9%)

Common (1% to 10%): Abdominal pain, diarrhea, dry mouth, nausea

Frequency not reported: Dyspepsia[Ref]

Dyspepsia was reported in less than 2% of patients.[Ref]

Hypersensitivity

Drug hypersensitivity was reported in less than 2% of patients. Anaphylaxis and pharyngeal edema have been reported with ingredients contained in this drug.[Ref]

Frequency not reported: Drug hypersensitivity

Postmarketing reports: Anaphylaxis, pharyngeal edema[Ref]

Cardiovascular

Tachycardia, palpitations, bradycardia, chest pain, and increased blood pressure were reported in less than 2% of patients.[Ref]

Common (1% to 10%): Peripheral edema

Frequency not reported: Tachycardia, palpitations, bradycardia, chest pain, increased blood pressure

Postmarketing reports: Myocardial ischemia, ventricular fibrillation (with oxycodone overdose)[Ref]

Psychiatric

Irritability, abnormal dreams, confusional state, disorientation, decreased libido, and drug abuse were reported in less than 2% of patients.[Ref]

Common (1% to 10%): Insomnia, depression, restlessness

Frequency not reported: Irritability, abnormal dreams, confusional state, disorientation, decreased libido, drug abuse[Ref]

Nervous system

Postmarketing reports of serotonin syndrome have been received among patients with concomitant use of opioids and serotonergic drugs.[Ref]

Common (1% to 10%): Dizziness, headache, hypoesthesia, somnolence, tremor

Postmarketing reports: Serotonin syndrome[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis, pruritus

Frequency not reported: Rash, urticaria[Ref]

Rash and urticaria were reported in less than 2% of patients.[Ref]

Endocrine

Decreased blood testosterone was reported in less than 2% of patients.[Ref]

Frequency not reported: Decreased blood testosterone

Postmarketing reports: Adrenal insufficiency, androgen deficiency[Ref]

Genitourinary

Frequency not reported: Dysuria, hematuria[Ref]

Dysuria and hematuria were reported in less than 2% of patients.[Ref]

Hematologic

Anemia and lymphadenopathy were reported in less than 2% of patients.[Ref]

Frequency not reported: Anemia, lymphadenopathy[Ref]

Hepatic

Abnormal liver function test was reported in less than 2% of patients.[Ref]

Frequency not reported: Abnormal liver function test[Ref]

Metabolic

Decreased appetite and gout were reported in less than 2% of patients.[Ref]

Frequency not reported: Decreased appetite, gout[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia, muscle spasms

Frequency not reported: Myalgia, muscle twitching, musculoskeletal stiffness, arthritis[Ref]

Myalgia, muscle twitching, musculoskeletal stiffness, and arthritis were reported in less than 2% of patients.[Ref]

Ocular

Frequency not reported: Increased lacrimation[Ref]

Increased lacrimation was reported in less than 2% of patients.[Ref]

Other

Common (1% to 10%): Drug withdrawal syndrome, fatigue, hot flush

Frequency not reported: Vertigo, tinnitus, chills, pain, influenza like illness, pyrexia, malaise, intentional surgical and medical procedure misuse[Ref]

Vertigo, tinnitus, chills, pain, influenza like illness, pyrexia, malaise, and intentional surgical/medical procedure misuse were reported in less than 2% of patients.[Ref]

Frequently asked questions

References

1. Product Information. Troxyca ER (naltrexone-oxycodone). Pfizer U.S. Pharmaceuticals Group. 2016.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer