Sars-cov-2 (covid-19) mrna (tozinameran 12y+) bivalent booster vaccine Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 13, 2023.

Applies to sars-cov-2 (covid-19) mrna (tozinameran 12y+) bivalent booster vaccine: intramuscular suspension.

Serious side effects

Along with its needed effects, sars-cov-2 (covid-19) mrna (tozinameran 12y+) bivalent booster vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sars-cov-2 (covid-19) mrna (tozinameran 12y+) bivalent booster vaccine:

More common

• Chills
• diarrhea
• fever
• headache
• irritability
• joint or muscle pain
• swollen, painful, or tender lymph glands in the neck, armpit, or groin
• unusual tiredness or weakness

Less common

• Nausea
• vomiting

Rare

• Decreased appetite
• general feeling of discomfort or illness
• pain in the arms
• rash

Incidence not known

• Anxiety
• blue or pale skin
• chest discomfort or tightness
• chest pain, possible moving to the left arm, neck, or shoulder
• cough
• difficulty swallowing
• dizziness
• fainting
• fast heartbeat
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• trouble breathing

Other side effects

Some side effects of sars-cov-2 (covid-19) mrna (tozinameran 12y+) bivalent booster vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Pain, redness, or swelling at the injection site

For Healthcare Professionals

Applies to sars-cov-2 (covid-19) mrna (tozinameran 12y+) bivalent booster vaccine: intramuscular suspension.

General

The most commonly reported side effects included injection site pain, fatigue, headache, and myalgia.^[Ref]

Cardiovascular

Postmarketing reports: Myocarditis, pericarditis^[Ref]

Dermatologic

Postmarketing reports: Angioedema, erythema multiforme, pruritus, skin rash, urticaria^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 13.7%)

Common (1% to 10%): Vomiting

Uncommon (0.1% to 1%): Nausea^[Ref]

Hematologic

Uncommon (0.1% to 1%): Lymphadenopathy^[Ref]

Hypersensitivity

Postmarketing reports: Anaphylaxis, severe allergic reactions^[Ref]

Local

Very common (10% or more): Injection site pain (up to 79.4%)

Common (1% to 10%): Injection site redness, injection site swelling^[Ref]

Metabolic

Uncommon (0.1% to 1%): Decreased appetite^[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (up to 33.7%), new/worsened muscle pain (up to 31.4%), arthralgia (up to 23.5%), new/worsened joint pain (up to 16.7%)

Common (1% to 10%): Extremity pain (arm)

Frequency not reported: Joint pain, muscle pain^[Ref]

Nervous system

Very common (10% or more): Headache (up to 47.6%)

Frequency not reported: Bell's palsy, facial paralysis

Postmarketing reports: Dizziness, hypoesthesia, paresthesia^[Ref]

Bell's palsy was mild to moderate in severity, began 3 to 48 days after the last dose, included facial paralysis and facial paresis, and typically lasted 3 to 68 days. This side effect was reported in 4 participants who received the vaccine and 2 patients who received a placebo, but a causal relationship to the vaccine could not be made.^[Ref]

Other

Very common (10% or more): Fatigue (up to 64.3%), use of antipyretic/pain medication (up to 46.7%), chills (up to 31.6%)

Common (1% to 10%): Fever (at least 38C)

Uncommon (0.1% to 1%): Malaise^[Ref]

Frequently asked questions

• Can you take Ibuprofen after the COVID booster vaccine?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer