Revcovi Side Effects

Generic name: elapegademase

Medically reviewed by Drugs.com. Last updated on Jul 21, 2023.

Note: This document contains side effect information about elapegademase. Some dosage forms listed on this page may not apply to the brand name Revcovi.

Applies to elapegademase: intramuscular solution.

Serious side effects of Revcovi

Along with its needed effects, elapegademase (the active ingredient contained in Revcovi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking elapegademase:

Rare

Black, tarry, stools
body aches or pain
burning, dry or itching eyes
change in hearing
chest pain
chills
cough
coughing or spitting up blood
diarrhea
difficulty in breathing
discharge, excessive tearing
ear congestion
ear drainage
earache
fever
general feeling of discomfort or illness
headache
itching in the genitals or other skin areas
itching of the ears
joint pain
loss of appetite
loss of voice
lower back or side pain
muscle aches and pains
nasal congestion
nausea
painful or difficult urination
pale skin
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
runny nose
scaling
seizures
severe pain in the side and back
shivering
sneezing
sore mouth or tongue
sore throat
stiff neck
stomach cramps and pain
sweating
swollen, painful, or tender lymph glands in the neck, armpit, or groin
thickening of bronchial secretions
trouble sleeping
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual tiredness or weakness
vomiting
watery diarrhea

Incidence not known

Back, leg, or stomach pains
bleeding gums
blood in the urine or stools
dark urine
dizziness
general body swelling
nosebleeds
pain, warmth, or burning in the fingers, toes, and legs
pinpoint red spots on the skin
problems with vision or hearing
weight loss
yellowing of the eyes or skin

Other side effects of Revcovi

Some side effects of elapegademase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Change in walking and balance
clumsiness or unsteadiness
difficulty in moving
ear canal irritation
headache, severe and throbbing
injection site discomfort
lack or loss of strength
mouth or throat pain
muscle pain or stiffness
rash
swelling of the face or nose
tearing of the skin
tooth pain
upper stomach pain

Incidence not known

Redness and itching at the injection site

For Healthcare Professionals

Applies to elapegademase: intramuscular solution.

Hematologic

Very common (10% or more): Lymphadenopathy (16%)

Postmarketing reports: Hemolytic anemia, autoimmune hemolytic anemia, thrombocythemia, autoimmune thrombocytopenia^[Ref]

Immunologic

Very common (10% or more): Influenza (16%), stoma site infection (16%)

Frequency not reported: Immunogenicity^[Ref]

Local

Postmarketing reports: Injection site erythema^[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (16%)^[Ref]

Ocular

Very common (10% or more): Conjunctivitis (16%)^[Ref]

Metabolic

Very common (10% or more): Injection site discomfort (16%), laceration (16%)^[Ref]

Genitourinary

Very common (10% or more): Groin abscess (16%)^[Ref]

Oncologic

Postmarketing reports: Lymphomas^[Ref]

Respiratory

Very common (10% or more): Cough (50%), productive cough (16%), epistaxis (16%), pulmonary haemophilus infection (16%), hemoptysis (16%), nasal edema (16%), upper respiratory tract infection (16%)^[Ref]

Other

Very common (10% or more): Fatigue (16%), cerumen impaction (16%), ear canal irritation (16%), ear lobe infection (16%), otitis externa (16%)^[Ref]

General

The most common adverse effects were cough (50%) and vomiting (33%)^[Ref]

Nervous system

Very common (10% or more): Asthenia (16%), convulsion (16%), gait disturbance (16%), migraine (16%)^[Ref]

Renal

Very common (10% or more): Nephrolithiasis (16%)^[Ref]

Dermatologic

Very common (10% or more): Fungal skin infection (16%), rash (16%), face swelling (16%)

Postmarketing reports: Urticaria^[Ref]

Gastrointestinal

Very common (10% or more): Vomiting (33%), abdominal pain upper (16%), dental caries (16%), tooth abscess (16%), tooth extraction (16%), diarrhea (16%), GI infection (16%), hematochezia (16%), nausea (16%), oral candidiasis (16%), oropharyngeal pain (16%)^[Ref]