Pyrazinamide Side Effects
Medically reviewed by Drugs.com. Last updated on Jun 14, 2023.
Applies to pyrazinamide: oral tablet.
Serious side effects of Pyrazinamide
Along with its needed effects, pyrazinamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking pyrazinamide:
More common
- Pain in large and small joints
Rare
- Loss of appetite
- pain and swelling of joints, especially big toe, ankle, and knee
- tense, hot skin over affected joints
- unusual tiredness or weakness
- yellow eyes or skin
Other side effects of Pyrazinamide
Some side effects of pyrazinamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Rare
For Healthcare Professionals
Applies to pyrazinamide: oral tablet.
Musculoskeletal
Common (1% to 10%): Mild arthralgia, myalgia
Frequency not reported: Arthralgia[Ref]
Hematologic
Rare (0.01% to 0.1%): Adverse effects on blood clotting mechanisms, erythrocyte vacuolation, sideroblastic anemia, thrombocytopenia
Frequency not reported: Splenomegaly[Ref]
Metabolic
Rare (0.01% to 0.1%): Increased serum iron concentration, porphyria
Frequency not reported: Anorexia, gout/active gout[Ref]
Dermatologic
Rare (0.01% to 0.1%): Acne, photosensitivity
Frequency not reported: Pruritus, rashes, urticaria[Ref]
Other
Rare (0.01% to 0.1%): Fever
Frequency not reported: Malaise[Ref]
Genitourinary
Rare (0.01% to 0.1%): Dysuria[Ref]
Renal
Rare (0.01% to 0.1%): Interstitial nephritis[Ref]
Oncologic
Rare (0.01% to 0.1%): Erythroid hyperplasia[Ref]
Hepatic
Frequency not reported: Clinical jaundice, hepatic failure/fatal hepatic failure, hepatic reaction, hepatomegaly, hepatotoxicity, liver tenderness, symptomless abnormality of hepatic cell function[Ref]
Hepatotoxicity may be dose-related, and can occur at any time during treatment.[Ref]
Gastrointestinal
Frequency not reported: Aggravation of peptic ulcer, nausea, vomiting[Ref]
Hypersensitivity
Frequency not reported: Hypersensitivity reactions[Ref]
Cardiovascular
Frequency not reported: Flushing[Ref]
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References
1. Product Information. Pyrazinamide (pyrazinamide). VersaPharm Inc. 2001;PROD.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.