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Motegrity Side Effects

Generic name: prucalopride

Medically reviewed by Drugs.com. Last updated on Dec 27, 2023.

Note: This document contains side effect information about prucalopride. Some dosage forms listed on this page may not apply to the brand name Motegrity.

Applies to prucalopride: oral tablet.

Serious side effects of Motegrity

Along with its needed effects, prucalopride (the active ingredient contained in Motegrity) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking prucalopride:

Less common

Rare

Incidence not known

Other side effects of Motegrity

Some side effects of prucalopride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to prucalopride: oral tablet.

General

The most commonly reported side effects included headache, abdominal pain, nausea, and diarrhea.[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 19.6%), Abdominal pain (up to 16%), diarrhea (up to 13%)

Common (1% to 10%): Abdominal distention, abnormal bowel sounds, abnormal gastrointestinal sounds, dyspepsia, flatulence, rectal hemorrhage, upper abdominal pain, vomiting

Uncommon (0.1% to 1%):

Frequency not reported: Abdominal discomfort, abdominal tenderness, epigastric discomfort, lower abdominal pain[Ref]

Diarrhea occurred within the first week in 70% of those reporting the side effect, and usually resolved within a few days in 73% of the patients. Severe diarrhea occurred in approximately 1.3% of patients.[Ref]

Nervous system

Very common (10% or more): Headache (up to 24.2%)

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Tremors

Frequency not reported: Migraine[Ref]

Headache occurred within the first 2 days in 66% of patients who reported the side effect, and usually resolved within a few days in 65% of the patients.[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, sinusitis

Postmarketing reports: Dyspnea[Ref]

Other

Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Fever/pyrexia, malaise[Ref]

Metabolic

Common (1% to 10%): Decreased appetite

Uncommon (0.1% to 1%): Anorexia[Ref]

Musculoskeletal

Common (1% to 10%): Back pain[Ref]

Immunologic

Common (1% to 10%): Influenza[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Palpitations[Ref]

Dermatologic

Postmarketing reports: Facial edema, pruritus, rash, urticaria[Ref]

Genitourinary

Common (1% to 10%): Polyuria, urinary tract infection

Uncommon (0.1% to 1%): Pollakiuria[Ref]

Frequently asked questions

References

1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Resotran (prucalopride). Janssen Pharmaceuticals. 2012.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer