Lutathera Side Effects

Generic name: lutetium lu 177 dotatate

Medically reviewed by Drugs.com. Last updated on Dec 20, 2023.

Note: This document contains side effect information about lutetium lu 177 dotatate. Some dosage forms listed on this page may not apply to the brand name Lutathera.

Applies to lutetium lu 177 dotatate: intravenous solution.

Serious side effects of Lutathera

Along with its needed effects, lutetium lu 177 dotatate (the active ingredient contained in Lutathera) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lutetium lu 177 dotatate:

More common

Agitation
anxiety
black, tarry stools
bleeding gums
blood in the urine or stools
blurred vision
chills
cold sweats
confusion
cool, pale skin
cough
decreased urine output
diarrhea
difficulty in breathing
dizziness
dry mouth
feeling of warmth
fever
flushed, dry skin
fruit-like breath odor
headache
hoarseness
hostility
increased hunger
increased thirst
increased urination
irritability
joint pain, stiffness, or swelling
loss of appetite
loss of consciousness
lower back, side, arm, leg, or stomach pain
mood changes
mood or mental changes
muscle cramps in the hands, arms, feet, legs, or face
muscle pain or twitching
nausea
nervousness
nightmares
numbness and tingling around the mouth, lips, hands, fingertips, or feet
painful or difficult urination
pale skin
pinpoint red spots on the skin
pounding in the ears
rapid weight gain
redness of the face, neck, arms, and occasionally, upper chest
restlessness
seizures
shakiness
slow, fast, or irregular heartbeat
slurred speech
sore throat
sweating
swelling of the face, feet, lower legs, ankles, or hands
tremor
troubled breathing
troubled breathing with exertion
ulcers, sores, or white spots in the mouth
unexplained weight loss
unusual bleeding or bruising
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
vomiting
weakness or heaviness of the legs

Less common

Bone pain
chest pain or discomfort
dilated neck veins
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
extreme tiredness or weakness
irregular breathing
pain or discomfort in the arms, jaw, back, or neck
swollen glands

Other side effects of Lutathera

Some side effects of lutetium lu 177 dotatate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation
decreased appetite
hair loss or thinning of the hair
loss or change in taste

Less common

Difficulty in moving
neck pain

For Healthcare Professionals

Applies to lutetium lu 177 dotatate: intravenous solution.

Hematologic

Common (1% to 10%): Lymphopenia, leukopenia, neutropenia, thrombocytopenia, anemia^[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, pain in extremity, myalgia, neck pain^[Ref]

Metabolic

Common (1% to 10%): Decreased appetite, hyperglycemia, hypocalcemia, hypokalemia, hyperkalemia, hypernatremia, hypoglycemia^[Ref]

Psychiatric

Common (1% to 10%): Anxiety^[Ref]

Hepatic

Common (1% to 10%): GGT increased, alkaline phosphatase increased, AST increased, ALT increased, blood bilirubin increased^[Ref]

Respiratory

Common (1% to 10%): Cough^[Ref]

Other

Common (1% to 10%): Fatigue, peripheral edema, pyrexia^[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, dysgeusia^[Ref]

Renal

Common (1% to 10%): Renal failure (glomerular filtration rate decreased, acute kidney injury, acute prerenal failure, azotemia, renal disorder, renal failure, renal impairment); hyperuricemia; creatinine increased^[Ref]

Cardiovascular

Common (1% to 10%): Atrial fibrillation, flushing, hypertension^[Ref]

Dermatologic

Common (1% to 10%): Alopecia

Gastrointestinal

Common (1% to 10%): Nausea, vomiting abdominal pain, diarrhea, constipation^[Ref]

Genitourinary

Common (1% to 10%): Radiation related urinary tract toxicity (dysuria, micturition urgency, nocturia, pollakiuria, renal colic, renal pain, urinary tract pain and urinary incontinence)