Kynamro Side Effects

Generic name: mipomersen

Medically reviewed by Drugs.com. Last updated on Jun 16, 2023.

Note: This document contains side effect information about mipomersen. Some dosage forms listed on this page may not apply to the brand name Kynamro.

Applies to mipomersen: subcutaneous solution.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using mipomersen (the active ingredient contained in Kynamro) and call your doctor at once if you have:

• flu symptoms within 2 days after an injection--fever, chills, body aches, tired feeling, joint or muscle pain;

• pain, swelling, redness, itching, bruising, or tenderness where an injection was given; or

• nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• nausea;

• headache; or

• flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to mipomersen: subcutaneous solution.

Cardiovascular

Common (1% to 10%): Hypertension (7%), angina pectoris (4%), palpitations (3%)^[Ref]

Dermatologic

Very common (10% or more): [All injection site reactions (84%)], erythema (59%), pain (56%), hematoma (32%), pruritus (29%), swelling (18%), discoloration (17%)^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (14%)

Common (1% to 10%): Vomiting (4%), abdominal pain (3%)^[Ref]

Hepatic

Very common (10% or more): Alanine aminotransferase (ALT) increased (10%)

Common (1% to 10%): Hepatic steatosis (7%), aspartate aminotransferase (AST) increased (6%), liver function test abnormal (5%), hepatic enzyme increased (3%)^[Ref]

Immunologic

Rare (less than 0.1%): One case of hypersensitivity with angioedema was reported^[Ref]

Metabolic

Common (1% to 10%): Proteinuria (9%), peripheral edema (5%)^[Ref]

Musculoskeletal

Common (1% to 10%): Pain in extremity (7%), musculoskeletal pain (4%)^[Ref]

Nervous system

Very common (10% or more): Fatigue (15%), headache (12%)

Common (1% to 10%): Pyrexia (8%), chills (6%)^[Ref]

Oncologic

Common (1% to 10%): Neoplasms [benign and malignant] (4%)^[Ref]

Psychiatric

Common (1% to 10%): Insomnia (3%)^[Ref]

Renal

Rare (less than 0.1%): One case of glomerular nephritis was reported^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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