Kerendia Side Effects

Generic name: finerenone

Medically reviewed by Drugs.com. Last updated on Aug 3, 2023.

Note: This document contains side effect information about finerenone. Some dosage forms listed on this page may not apply to the brand name Kerendia.

Applies to finerenone: oral tablet.

Serious side effects of Kerendia

Along with its needed effects, finerenone (the active ingredient contained in Kerendia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking finerenone:

More common

Confusion
irregular heartbeat
nausea or vomiting
nervousness
numbness or tingling in the hands, feet, or lips
stomach pain
trouble breathing
weakness or heaviness of the legs

Less common

Blurred vision
coma
decreased urine output
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fast heartbeat
headache
increase thirst
muscle pain or cramps
seizures
sweating
swelling of the face, ankles, or hands
unusual tiredness or weakness

For Healthcare Professionals

Applies to finerenone: oral tablet.

General

The most frequently reported adverse reaction was hyperkalemia.^[Ref]

Cardiovascular

Common (1% to 10%): Hypotension (includes blood pressure decreased, diastolic blood pressure decreased, diastolic hypotension, hypotension)

Frequency not reported: Systolic blood pressured decreased, diastolic blood pressure decreased^[Ref]

In patients treated with this drug, the mean systolic and diastolic blood pressure decreased by 2 to 4 mmHg and 1 to 2 mmHg, respectively, at month 1 and remained stable thereafter. Most hypotension events were mild or moderate and resolved; events associated with hypotension (e.g., dizziness, syncope, fall) were not more frequent in patients treated with this drug compared to placebo.^[Ref]

Dermatologic

Common (1% to 10%): Pruritus^[Ref]

Hematologic

Common (1% to 10%): Anemia

Uncommon (0.1% to 1%): Hemoglobin decreased

Frequency not reported: Hematocrit decreased^[Ref]

Metabolic

Very common (10% or more): Serum potassium increased (up to 21.7%), hyperkalemia (includes blood potassium increased, hyperkalemia; up to 18.3%)

Common (1% to 10%): Hyponatremia (includes blood sodium decreased, hyponatremia)^[Ref]

In a study, hyperkalemia events were reported in 18.3% of patients treated with this drug; most hyperkalemia events were mild to moderate in patients treated with this drug. Serious hyperkalemia events were report more often for this drug than placebo; serum potassium levels greater than 5.5 mmol/L and greater than 6 mmol/L were reported in 21.7% and 4.5% of patients treated with this drug and in 9.8% and 1.4% of those treated with placebo, respectively.

An increase from baseline in mean serum potassium in the first month of therapy was about 0.2 mmol/L in patients treated with this drug.^[Ref]

Nervous system

Frequency not reported: Dizziness, syncope^[Ref]

Other

Frequency not reported: Fall^[Ref]

Renal

Common (1% to 10%): Estimated glomerular filtration rate (eGFR) decreased/GFR decreased^[Ref]

This drug caused an initial small decrease in eGFR (mean 2 mL/min/1.73 m2); it occurred within the first 4 weeks of therapy and then stabilized. In a study including patients with chronic kidney disease associated with type 2 diabetes, this decrease was reversible after therapy was stopped.^[Ref]