Hemin Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 15, 2023.

Applies to hemin: intravenous powder for solution.

Serious side effects of Hemin

Along with its needed effects, hemin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hemin:

Less common

Bluish color
changes in skin color
fever
itching, pain, redness, swelling, tenderness, or warmth on the skin
redness or pain at the catheter site
swelling of the foot or leg tenderness

Incidence not known

Back pain
black, tarry stools
bleeding gums
blood in the urine or stools
dark urine
decreased urination
dizziness
fainting
fever
irregular heartbeat
lightheadedness
pinpoint red spots on the skin
stomach pain
tiredness
unusual bleeding or bruising
yellow eyes or skin

Other side effects of Hemin

Some side effects of hemin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Headache

Less common

Rash

Incidence not known

Dry, red, hot, or irritated skin

For Healthcare Professionals

Applies to hemin: intravenous powder for injection.

General

The most frequently reported adverse reactions included headache, pyrexia, infusion site reactions, and phlebitis.^[Ref]

Cardiovascular

Very common (10% or more): Poor venous access

Common (1% to 10%): Phlebitis

Uncommon (0.1% to 1%): Venous thrombosis^[Ref]

Phlebitis with or without leukocytosis and with or without mild pyrexia was observed after administration of this drug through small arm veins.^[Ref]

Dermatologic

Common (1% to 10%): Rash, cellulitis

Frequency not reported: Dermatitis medicamentosa^[Ref]

Gastrointestinal

Frequency not reported: Tongue edema

Hematologic

Frequency not reported: Leukocytosis

Postmarketing reports: Thrombocytopenia, coagulopathy, hemolysis^[Ref]

Coagulopathy included prolonged prothrombin time and prolonged partial thromboplastin time.^[Ref]

Hypersensitivity

Rare (0.01% to 0.1%): Anaphylactoid reaction, hypersensitivity^[Ref]

Hypersensitivity reactions included a report of an infusion-related anaphylactoid reaction presenting as circulatory collapse.^[Ref]

Local

Common (1% to 10%): Injection site phlebitis, infusion site pain, infusion site swelling

Uncommon (0.1% to 1%): Injection site thrombosis

Frequency not reported: Infusion site erythema, infusion site bleeding, infusion site extravasation^[Ref]

Metabolic

Postmarketing reports: Iron overload^[Ref]

Nervous system

Common (1% to 10%): Headache

Other

Common (1% to 10%): Pyrexia, catheter-related complications

Uncommon (0.1% to 1%): Increased serum ferritin

Catheter-related complications included erythema, pain, bleeding, extravasation, and infusion site swelling.

Increased serum ferritin concentration has been reported after several years of treatment with repeated infusions, which may indicate an iron overload.