Chlorpheniramine / guaifenesin / hydrocodone / pseudoephedrine Side Effects
Applies to chlorpheniramine / guaifenesin / hydrocodone / pseudoephedrine: oral liquid.
Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough and cold medicine before the MAO inhibitor has cleared from your body.
Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.
Do not give this medication to a child younger than 6 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Ask a doctor or pharmacist before using any other cough, cold, allergy, or sleep medicine. Chlorpheniramine, guaifenesin, and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, decongestant, or expectorant.
Get emergency medical help if you have any of these signs of an allergic reaction while taking chlorpheniramine / guaifenesin / hydrocodone / pseudoephedrine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking this medication and call your doctor at once if you have a serious side effect such as:
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severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor;
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fast, pounding, or uneven heartbeats;
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slow heartbeat, weak pulse, shallow breathing;
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confusion, hallucinations, unusual thoughts or behavior;
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ringing in your ears;
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painful or difficult urination;
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pale skin, easy bruising or bleeding, unusual weakness; or
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increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).
Less serious side effects of chlorpheniramine / guaifenesin / hydrocodone / pseudoephedrine may include:
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dizziness, drowsiness, headache;
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blurred vision;
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dry mouth, nose, or throat;
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nausea, stomach pain, constipation; or
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restless or excitability (especially in children).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
More about chlorpheniramine / guaifenesin / hydrocodone / pseudoephedrine
- Check interactions
- Compare alternatives
- Dosage information
- Drug class: upper respiratory combinations
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
