Acetaminophen / dextromethorphan / diphenhydramine Side Effects
Medically reviewed by Drugs.com. Last updated on Mar 11, 2024.
Applies to acetaminophen / dextromethorphan / diphenhydramine: oral liquid.
Warning
Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Use this medicine exactly as directed. An overdose of acetaminophen can damage your liver or cause death. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.
Do not use this medicine to make a child sleepy. Ask a doctor before giving the medicine to a child younger than 12 years old.
Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen or diphenhydramine. Taking too much of either medicine can lead to a fatal overdose.
Drinking alcohol may increase your risk of liver damage while taking acetaminophen.
Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.
Stop using this medicine and call your doctor at once if you have:
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fast, pounding, or uneven heartbeats;
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severe drowsiness;
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painful or difficult urination;
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severe headache, seizure; or
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liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
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drowsiness;
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headache, sleep problems (insomnia);
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dry eyes, blurred vision;
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dry mouth, nose, or throat; or
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feeling restless or excited (especially in children).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to acetaminophen/dextromethorphan/diphenhydramine: oral liquid.
General
The manufacturer has not provided adverse event information.[Ref]
More about acetaminophen / dextromethorphan / diphenhydramine
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- Drug class: upper respiratory combinations
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References
1. Product Information. Diabetic Tussin Night Time Formula (acetaminophen/DM/diphenhydramine). Health Care Products. 2022.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
