Skip to main content

Cortrosyn Dosage

Generic name: Cosyntropin 0.25mg in 1mL
Dosage form: injection, powder, lyophilized, for solution
Drug class: Corticotropin

Medically reviewed by Drugs.com. Last updated on Dec 1, 2024.

Important Information Before Conducting CORTROSYN TESTING

  • In general, stop glucocorticoids and spironolactone on the day of CORTROSYN testing. However, long-acting glucocorticoids may need to be stopped for a longer period before CORTROSYN testing [see Warnings and Precautions (5.2), Drug Interactions (7)].
  • Stop estrogen-containing drugs four to six weeks before CORTROSYN testing [see Warnings and Precautions (5.2), Drug Interactions (7)].

Recommended Dose for Adults

  • The recommended dose of CORTROSYN in adults is 0.25 mg to be administered by intravenous or intramuscular injection.

Recommended Dose for Pediatric Patients

  • The recommended dose of CORTROSYN in pediatric patients, aged birth to 17 years, to be administered by intravenous or intramuscular injection is presented in Table 1.
Table 1. Recommended CORTROSYN Dose for Pediatric Patients
Age Recommended Dose Volume of Reconstituted Solution
Birth to less than 2 years 0.125 mg 0.5 mL
2 to 17 years 0.25 mg 1 mL

Reconstitution Instructions

  • Aseptically reconstitute the lyophilized powder in the vial using 1 mL of 0.9% Sodium Chloride Injection, USP and gently swirl.
  • After reconstitution, the final concentration of CORTROSYN reconstituted solution is 0.25 mg/mL.
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. The reconstituted CORTROSYN solution should be clear and colorless, and free of particulates. If CORTROSYN solution is cloudy or contains particulates, do not administer.
  • If the CORTROSYN reconstituted solution is not used immediately, discard the unused CORTROSYN reconstituted solution.

Administration Information

  • CORTROSYN may be administered by intramuscular or intravenous injection.
  • Obtain blood sample for baseline serum cortisol. Obtain blood samples again for assessment of cortisol levels exactly 30 minutes and 60 minutes after administration of CORTROSYN.

Interpretation of Plasma Cortisol Levels After CORTROSYN Injection

  • Stimulated plasma cortisol levels of less than 18 mcg/dL at 30- or 60-minutes post CORTROSYN injection are suggestive of adrenocortical insufficiency. Cutoff values for exclusion of adrenocortical insufficiency may vary according to the assay used. Test results can be affected by concomitant medications and certain medical conditions [see Warnings and Precautions (5.2)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer