Corticorelin Dosage
Applies to the following strengths: 100 mcg
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Cushing's Syndrome
Testing dose: 1 mcg/kg IV over 30 seconds
- Doses greater than 1 mcg/kg are not recommended
Comments:
- Some adverse effects can be reduced by administering the drug as an infusion over 30 seconds instead of as a bolus injection.
Use: Differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
Usual Pediatric Dose for Cushing's Syndrome
Testing dose: 1 mcg/kg IV over 30 seconds
- Doses greater than 1 mcg/kg are not recommended
Comments:
- Limited data in pediatric patients.
- Some adverse effects can be reduced by administering the drug as an infusion over 30 seconds instead of as a bolus injection.
Use: Differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to ovine corticorelin or any product excipients
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- For intravenous injection only
- Some of the adverse effects can be reduced by administering as an infusion over 30 seconds instead of as a bolus injection
Reconstitution/preparation techniques:
- Reconstitute vial with 2 mL of solidum chloride injection; to avoid bubble formation, do not shake
- Roll the vial to dissolve product
Storage:
- Store refrigerated 2C to 8C (36F to 46F); protect from light
- Reconstituted solution: Stable for up to 8 hours when refrigerated
General:
- If a repeated evaluation is needed, the repeat test should be carried out at the same time of day as the original test.
- ACTH and cortisol responses are prolonged and remain elevated for up to 2 hours; maximum increment in plasma ACTH occurs between 15 and 60 minutes following administration with the maximum increment in plasma cortisol occurring between 30 and 120 minutes
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
