Acetaminophen / Pheniramine / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on Aug 2, 2023.

Applies to the following strengths: 325 mg-20 mg-10 mg; 650 mg-20 mg-10 mg

Usual Adult Dose for Cold Symptoms

Acetaminophen 325 mg/ pheniramine 20 mg/ phenylephrine 10 mg packets: 1 packet in water every 4 hours
Maximum dose: 3 packets per 24 hours

Acetaminophen 650 mg/ pheniramine 20 mg/ phenylephrine 10 mg packets: 1 packet in water every 4 hours
Maximum dose: 5 packets per 24 hours

Usual Pediatric Dose for Cold Symptoms

Acetaminophen 325 mg/ pheniramine 20 mg/ phenylephrine 10 mg packets:
12 years and older: 1 packet in water every 4 hours
Maximum dose: 3 packets per 24 hours

Acetaminophen 650 mg/ pheniramine 20 mg/ phenylephrine 10 mg packets:
12 years and older: 1 packet in water every 4 hours
Maximum dose: 5 packets per 24 hours

Renal Dose Adjustments

Use with caution in severe renal disease.

Liver Dose Adjustments

Use with caution in severe hepatic disease.

Precautions

CONTRAINDICATIONS:

Hypersensitivity to any of the ingredients
Current use of any other drug containing acetaminophen.
Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
Use with caution in marked coronary atherosclerosis, arterial hypertension, narrow-angle glaucoma, severe hepatic or renal disease, prostatic hyperplasia, blood diseases, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, and Rotor syndromes), hyperthyroidism, pheochromocytoma, and bronchial asthma.

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

Dissolve packets in 8 ounces hot water; sip while hot and consume entire drink within 10 to 15 minutes
If microwaving, add packet to 8 ounces cold water; stir briskly before and after heating; do not overheat.
May add sugar to taste.

Patient advice:

Do not use more than directed.
Avoid alcoholic drinks.
Keep out of reach of children.
Drowsiness may occur; concomitant sedatives or tranquilizer may increase drowsiness.
Discontinue for nervousness, dizziness, or sleepiness.
Use caution if driving a motor vehicle or operating machinery.