Acetaminophen / dextromethorphan / doxylamine / phenylephrine Alternatives Compared
Acetaminophen / dextromethorphan / doxylamine / phenylephrine | Benadryl | Diphenhydramine |
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Acetaminophen / dextromethorphan / doxylamine / phenylephrine | Benadryl (diphenhydramine) | Diphenhydramine |
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Over-the-counter
Prescribed for Rhinorrhea, Cough and Nasal Congestion, Nasal Congestion, Cough, Cold Symptoms, Pain/Fever. acetaminophen / dextromethorphan / doxylamine / phenylephrine may also be used for purposes... View more |
Prescription and OTC
Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more |
Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
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More about Acetaminophen / dextromethorphan / doxylamine / phenylephrine | More about Benadryl (diphenhydramine) | More about Diphenhydramine | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Acetaminophen / dextromethorphan / doxylamine / phenylephrine has an average rating of 5.5 out of 10 from a total of 3 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 50% reported a negative effect. |
Benadryl has an average rating of 7.2 out of 10 from a total of 76 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect. |
Diphenhydramine has an average rating of 5.4 out of 10 from a total of 528 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 41% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: acetaminophen / dextromethorphan / doxylamine / phenylephrine side effects in more detail. |
See also: Benadryl side effects in more detail. |
See also: diphenhydramine side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
Lower cost generic |
N/A |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all acetaminophen / dextromethorphan / doxylamine / phenylephrine prices |
View all Benadryl prices |
View all diphenhydramine prices |
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Dosage Form(s) Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Liquid Gels (Night Formula), Alka-Seltzer Plus Maximum Strength Night Cold & Flu Liquid Gels, Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula), Alka-Seltzer Plus Multi-Symptom Cold & Flu Day & Night Liquid Gels (Night Formula), Alka-Seltzer Plus Night Cold Formula Liquid, Alka-Seltzer Plus Night Severe Cold+Flu Hot Drink Mix, Alka-Seltzer Plus Severe Cold & Flu Day & Night (Night Formula), Alka-Seltzer Plus Severe Sinus Congestion & Cough (Night Formula), Alka-Seltzer Plus Severe Sinus Congestion, Allergy & Cough Liquid Gels, Delsym Night Time Multi-Symptom, Mucinex Fast-Max Night Time Cold & Flu Liquid Gels, Tylenol Cold Multi-Symptom Nighttime Liquid, Vicks NyQuil Severe Cold & Flu View more | Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
N/A |
9.3 hours |
9.3 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Category N
Not classified
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 603 drugs are known to interact with acetaminophen / dextromethorphan / doxylamine / phenylephrine:
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A total of 446 drugs are known to interact with Benadryl:
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A total of 446 drugs are known to interact with diphenhydramine:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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Disease Interactions | ||||||||||||||||||||||||||
First Approval Date | ||||||||||||||||||||||||||
N/A |
March 04, 1946 |
March 04, 1946 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
N/A |
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Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.