Cerebral Small Vessel Disease Predicts Intracranial Hemorrhage With Antithrombotics
By Lori Solomon HealthDay Reporter
MONDAY, Jan. 8, 2024 -- Cerebral small vessel disease (SVD) predicts intracranial hemorrhage for patients with cerebrovascular or cardiovascular disease taking antithrombotic therapy, according to a study published online Dec. 25 in the Annals of Neurology.
Kanta Tanaka, M.D., Ph.D., from the National Cerebral and Cardiovascular Center in Suita, Japan, and colleagues determined the excess risk for antithrombotic-related bleeding due to cerebral SVD burden. The analysis included 5,250 patients (median age, 73 years) with cerebrovascular or cardiovascular disease taking oral antithrombotic agents across Japan between 2016 and 2019.
The researchers found that the incidence rate of major bleeding was 0.39 per 100 person-years with SVD score 0; 0.56 with SVD score 1; 0.91 with SVD score 2; 1.35 with SVD score 3; and 2.24 with SVD score 4. For intracranial hemorrhage, the incidence rates were 0.11, 0.33, 0.58, 0.99, and 1.06, respectively, across SVD scores; the corresponding ischemic event incidence rates were 1.82, 2.27, 3.04, 3.91, and 4.07. There was a significantly elevated risk seen for extracranial major bleeding and gastrointestinal bleeding for SVD score 4 versus 0.
"Total SVD score was predictive for intracranial hemorrhage and probably for extracranial bleeding, suggesting the broader clinical relevance of cerebral SVD as a marker for safe implementation of antithrombotic therapy," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted January 2024
Read this next
Several Drugs Linked to Risk for Aneurysmal Subarachnoid Hemorrhage
THURSDAY, June 6, 2024 -- Several commonly prescribed drugs are associated with aneurysmal subarachnoid hemorrhage (aSAH), according to a study published online June 5 in...
Overweight in Teens, Young Adults Tied to Cerebrovascular Disease in Women
THURSDAY, June 6, 2024 -- Being overweight in adolescence or early adulthood is associated with an increased risk for cerebrovascular disease among women, according to a study...
Prevalence of Cardiovascular Risk Factors, Diseases Set to Increase
THURSDAY, June 6, 2024 -- The prevalence of cardiovascular risk factors and diseases will increase through 2050, and the associated economic burden is also projected to increase...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.